Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target

Bříza, T.; Králová, Jarmila; Rimpelová, S.; Havlík, M.; Kaplánek, R.; Kejik, Z.; Martásek, P.; Mikula, I.; Dzubak, P.; Hajduch, M.; Ruml, T.; Král, V.

doi:https://dx.doi.org/10.1016/j.bioorg.2018.02.011

Number of the records: 1

Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target

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SYSNO ASEP	0538135
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target
Author(s)	Bříza, T. (CZ) Králová, Jarmila (UMG-J)_RID Rimpelová, S. (CZ) Havlík, M. (CZ) Kaplánek, R. (CZ) Kejik, Z. (CZ) Martásek, P. (CZ) Mikula, I. (CZ) Dzubak, P. (CZ) Hajduch, M. (CZ) Ruml, T. (CZ) Král, V. (CZ)
Number of authors	12
Source Title	Bioorganic Chemistry. - : Elsevier - ISSN 0045-2068 Roč. 82, February (2019), s. 74-85
Number of pages	12 s.
Publication form	Online - E
Language	eng - English
Country	US - United States
Keywords	Anticancer activity ; Cytotoxicity ; Fluorescent cyanine ; Pentamethinium salt ; Recognition ; Sulfated polysaccharides
Subject RIV	EB - Genetics ; Molecular Biology
OECD category	Cell biology
R&D Projects	LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	UMG-J - RVO:68378050
UT WOS	000455479600009
DOI	10.1016/j.bioorg.2018.02.011
Annotation	A series of pentamethinium salts with benzothiazolium and indolium side units comprising one or two positive charges were designed and synthesized to determine the relationships among the molecular structure, charge density, affinity to sulfated polysaccharides, and biological activity. Firstly, it was found that the affinity of the pentamethinium salts to sulfated polysaccharides correlated with their biological activity. Secondly, the side heteroaromates displayed a strong effect on the cytotoxicity and selectivity towards cancer cells. Finally, doubly charged pentamethinium salts possessing benzothiazolium side units exhibited remarkably high efficacy against a taxol-resistant cancer cell line. (C) 2018 Published by Elsevier Inc.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/abs/pii/S0045206817306934?via%3Dihub

Number of the records: 1