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Current and Future Aspects of Nanomedicine
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SYSNO ASEP 0534382 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers Author(s) Bačáková, Lucie (FGU-C) RID, ORCID
Pajorová, Julia (FGU-C)
Zikmundová, Markéta (FGU-C)
Filová, Elena (FGU-C) RID, ORCID
Mikeš, P. (CZ)
Jenčová, V. (CZ)
Kuželová Košťáková, E. (CZ)
Sinica, A. (CZ)Source Title Current and Future Aspects of Nanomedicine. - London : IntechOpen, 2020 / Khalil Islam - ISBN 978-1-78985-870-9 Pages s. 1-30 Number of pages 30 s. Number of pages 142 Publication form Online - E Language eng - English Country GB - United Kingdom Keywords skin replacements ; wound dressings ; nanofibers ; electrospinning ; dermis ; epidermis ; keratinocytes ; fibroblasts ; stem cells ; vascularization ; cell delivery ; drug delivery ; regenerative medicine Subject RIV EI - Biotechnology ; Bionics OECD category Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) R&D Projects GA17-02448S GA ČR - Czech Science Foundation (CSF) GA17-00885S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 DOI 10.5772/intechopen.88602 Annotation Nanofibrous scaffolds belong to the most suitable materials for tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. This chapter is focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is the largest and vitally important organ in the human body. Nanofibrous meshes can serve as substrates for adhesion, growth and differentiation of skin and stem cells, and also as an antimicrobial and moisture-retaining barrier. These meshes have been prepared from a wide range of synthetic and nature-derived polymers. This chapter is focused on the use of nature-derived polymers. These polymers have good or limited degradability in the human tissues, which depends on their origin and on the presence of appropriate enzymes in the human tissues. Non-degradable and less-degradable polymers are usually produced in bacteria, fungi, algae, plants or insects, and include, for example, cellulose, dextran, pullulan, alginate, pectin and silk fibroin. Well-degradable polymers are usually components of the extracellular matrix in the human body or at least in other vertebrates, and include collagen, elastin, keratin and hyaluronic acid, although some polymers produced by non-vertebrate organisms, such as chitosan or poly(3-hydroxybutyrate-co-3-hydroxyvalerate), are also degradable in the human body. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://www.intechopen.com/online-first/nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-nature-derived-polymers
Number of the records: 1