The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

Dzianová, P.; Asai, Seiya; Chrudinová, Martina; Kosinová, L.; Potalitsyn, Pavlo; Šácha, Pavel; Hadravová, Romana; Selicharová, Irena; Kříž, J.; Turkenburg, J. P.; Brzozowski, A. M.; Jiráček, Jiří; Žáková, Lenka

doi:https://dx.doi.org/10.1098/rsob.200137

Number of the records: 1

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

1.

SYSNO ASEP	0533335
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels
Author(s)	Dzianová, P. (CZ) Asai, Seiya (UOCHB-X)_ORCID Chrudinová, Martina (UOCHB-X)_{RID, ORCID} Kosinová, L. (CZ) Potalitsyn, Pavlo (UOCHB-X)_{RID, ORCID} Šácha, Pavel (UOCHB-X)_{RID, ORCID} Hadravová, Romana (UOCHB-X)_{RID, ORCID} Selicharová, Irena (UOCHB-X)_{RID, ORCID} Kříž, J. (CZ) Turkenburg, J. P. (GB) Brzozowski, A. M. (GB) Jiráček, Jiří (UOCHB-X)_{RID, ORCID} Žáková, Lenka (UOCHB-X)_{RID, ORCID}
Article number	200137
Source Title	Open Biology. - : Royal Society Publishing Roč. 10, č. 10 (2020)
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	insulin ; zinc ; beta cells ; production ZnT8
Subject RIV	CE - Biochemistry
OECD category	Biochemistry and molecular biology
R&D Projects	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UOCHB-X - RVO:61388963
UT WOS	000586600500002
EID SCOPUS	85094221278
DOI	10.1098/rsob.200137
Annotation	Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However,the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. We showed that the disruption of zinc homeostasis in the model β-cells correlated with their impaired insulin and ZnT8 production. This indicates a need for in-depth fundamental research about the role of zinc in insulin production and storage.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2021
Electronic address	https://doi.org/10.1098/rsob.200137

Number of the records: 1