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Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances
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SYSNO ASEP 0508109 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances Author(s) Zálešák, F. (CZ)
Bon, D.J.Y.D. (CZ)
Pospíšil, Jiří (UEB-Q) ORCID, RID, SAINumber of authors 3 Article number 104284 Source Title Pharmacological Research. - : Elsevier - ISSN 1043-6618
Roč. 146, AUG (2019)Number of pages 27 s. Language eng - English Country GB - United Kingdom Keywords Bioactivity ; Lignans ; Neolignans ; Patentiflorin A ; Schibitubin B ; Schisanwilsonin G ; Terminaloside P Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemical research methods R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1304 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_019/0000738 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000482248300035 EID SCOPUS 85066271520 DOI 10.1016/j.phrs.2019.104284 Annotation Lignans and neolignans are plant secondary metabolites derived from the oxidative coupling of phenylpropanoids. Biological activity of these phenolic compounds ranges from antioxidant, antitumor (terminaloside P, IC50 = 10 nM), anti-inflammatory, anti-neurodegenerative (schibitubin B, IC50 = 3.2 nM)and antiviral (patentiflorin A, IC50 = 14–23 nM)to antimicrobial. In addition, it was observed that several members of this group, namely enterolactone and its biochemical precursors also known as phytoestrogens, possess important protective properties. Most of these lignans and neolignans are presented in reasonable amounts in one's diet and thus the protection they provide against the colon and breast cancer, to name a few, is even more important to note. Similarly, neuroprotective properties were observed (schisanwilsonin G, IC50 = 3.2 nM)These structural motives also serve as an important starting point in the development of anticancer drugs. Presumably the most famous members of this family, etoposide and teniposide, synthetic derivatives of podophyllotoxin, are used in the clinical treatment of lymphocytic leukemia, certain brain tumors, and lung tumors already for nearly 20 years. This review describes 413 lignans and neolignans which have been isolated between 2016 and mid-2018 being reported in more than 300 peer-reviewed articles. It covers their source, structure elucidation, and bioactivity. Within the review, the structure-based overview of compounds as well as the bioactivity-based overview of compounds are described. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2020 Electronic address http://dx.doi.org/10.1016/j.phrs.2019.104284
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