Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons

0504644 - FGÚ 2020 RIV DE eng J - Journal Article
Krůšek, Jan - Dittert, Ivan - Smejkalová, Tereza - Kořínek, Miloslav - Gottfriedová, K. - Freislebenová, Hana - Neuhöferová, Eva - Klimša, Ladislav - Sedláková, Silvia - Taylor, Andrew - Mortet, Vincent - Petrák, V. - Benson, Veronika - Petráková, V.
Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons.
Physica Status Solidi B. Roč. 256, č. 3 (2019), s. 1800424. ISSN 0370-1972. E-ISSN 1521-3951
R&D Projects: GA ČR(CZ) GA17-15319S; GA MŠMT(CZ) LM2015088; GA MŠMT(CZ) LO1409; GA MŠMT EF16_013/0001406; GA AV ČR(CZ) Fellowship J. E. Purkyně
Grant - others:AV ČR(CZ) Fellowship J. E. Purkyně; OP VVV - SAFMAT(XE) CZ.02.1.01/0.0/0.0/16_013/0001406
Program: Fellowship J. E. Purkyně
Research Infrastructure: SAFMAT II - 90088
Institutional support: RVO:67985823 ; RVO:61388971 ; RVO:68378271
Keywords : boron-doped diamond * chemical functionalization * enhanced surface area * nanocrystalline diamond * neural interface
OECD category: Neurosciences (including psychophysiology; Condensed matter physics (including formerly solid state physics, supercond.) (FZU-D); Biochemistry and molecular biology (MBU-M)
Impact factor: 1.481, year: 2019
Method of publishing: Limited access
https://doi.org/10.1002/pssb.201800424

This article examines the ability of newly developed nanostructured porous boron-doped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with poly-L-lysine.
Permanent Link: http://hdl.handle.net/11104/0296221