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Advances in Chemical Biology
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SYSNO ASEP 0502863 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Application of small molecular inhibitors for the establishment and maintenance of stem cell pluripotency Author(s) Chawengsaksophak, Kallayanee (UMG-J) ORCID
Schuster, Bjorn (UMG-J)
Epp, Trevor (UMG-J) RIDSource Title Advances in Chemical Biology. - Praha : OPTIO CZ, 2019 / Bartůněk Petr - ISBN 978-80-88011-03-3 Pages s. 20-31 Number of pages 11 s. Number of copy 50 Number of pages 210 Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords FAM208A ; HIV-2 auxiliary protein Vpx ; antiretroviral drug Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects LO1220 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMG-J - RVO:68378050 Annotation Retroviruses are not only equipped with machinery to replicate and propagate themselves, such as viral capsid proteins and reverse transcriptase enzymes, but often also contain auxiliary proteins which can either subvert the cellular machinery of the host towards their survival benefit or alternatively, overcome or otherwise temper the antiviral defensive responses of the infected host. Thus the study of retroviral auxiliary proteins and identification of their cellular targets has provided greater understanding of not only retroviral action but also antiviral immunity. Their discovery has spurned the search for small molecule inhibitors of these proteins and the respective host proteins in which they interact, with the aim to produce new antiviral treatments or to minimize any deleterious side-effects associated with retroviral auxiliary protein expression. Here we discuss some of the auxiliary proteins present in human immunodeficiency virus (HIV) and in particular, discuss the recent discovery of FAM208A as a direct target of the HIV-2 auxiliary protein Vpx. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2019
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