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Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection
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SYSNO ASEP 0482662 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection Author(s) Májovský, M. (CZ)
Řezáčová, Lenka (FGU-C) RID, ORCID, SAI
Sumová, Alena (FGU-C) RID, ORCID
Pospíšilová, L. (CZ)
Netuka, D. (CZ)
Bradáč, O. (CZ)
Beneš, V. (CZ)Source Title Journal of Clinical Neuroscience. - : Elsevier - ISSN 0967-5868
Roč. 39, May 2017 (2017), s. 155-163Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords melatonin ; circadian rhythm ; pineal cyst ; neurosurgery ; neuroendocrinology ; pinealectomy Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000399958200038 EID SCOPUS 85011976676 DOI 10.1016/j.jocn.2017.01.022 Annotation A pineal cyst is a benign affection of the human pineal gland on the borderline between pathology and normality. Only a small percentage of patients present with symptoms and a surgical treatment is indicated in highly selected cases. A melatonin secretion in patients with a pineal cyst before and after a pineal cyst resection has not been studied yet and the effect of surgery on human metabolism is unknown. The present study examined melatonin, cortisol and blood glucose secretion profiles perioperatively in a surgical group of 4 patients. The control group was represented by 3 asymptomatic patients with a pineal cyst. For each patient, 24-h circadian secretion curves of melatonin, cortisol and glycemia were acquired. An analysis of melatonin profiles showed an expected diurnal pattern with the night peak in patients before the surgery and in the control group. In contrast, melatonin levels in patients after the surgery were at their minimum throughout the whole 24-h period. The cortisol secretion was substantially increased in patients after the surgery. Blood glucose sampling showed no statistically significant differences. Clinical results demonstrated statistically significant headache relief measured by Visual Analogue Scale in patients after the surgery. Despite the small number of examined patients, we can conclude that patients with a pineal cyst preserved the physiological secretion of the hormone melatonin while patients who underwent the pineal cyst resection experienced a loss of endogenous pineal melatonin production, which equated with pinealectomy. Surprisingly, cortisol secretion substantially increased in patients after the surgery Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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