Adult neurogenesis reduction by a cytostatic treatment improves spatial reversal learning in rats

Brožka, Hana; Pištíková, Adéla; Radostová, Dominika; Valeš, Karel; Svoboda, Jan; Grzyb, A. N.; Stuchlík, Aleš

doi:https://dx.doi.org/10.1016/j.nlm.2017.03.018

Number of the records: 1

Adult neurogenesis reduction by a cytostatic treatment improves spatial reversal learning in rats

1.

SYSNO ASEP	0474955
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Adult neurogenesis reduction by a cytostatic treatment improves spatial reversal learning in rats
Author(s)	Brožka, Hana (FGU-C)_{ORCID, SAI, RID} Pištíková, Adéla (FGU-C) Radostová, Dominika (FGU-C)_{ORCID, RID, SAI} Valeš, Karel (FGU-C)_{RID, ORCID, SAI} Svoboda, Jan (FGU-C)_{RID, ORCID} Grzyb, A. N. (DE) Stuchlík, Aleš (FGU-C)_{RID, ORCID}
Source Title	Neurobiology of Learning and Memory. - : Elsevier - ISSN 1074-7427 Roč. 141, May (2017), s. 93-100
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	active avoidance ; hippocampus ; adult neurogenesis ; discrimination ; generalization ; reversal
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	GA14-03627S GA ČR - Czech Science Foundation (CSF)
	LH14053 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FGU-C - RVO:67985823
UT WOS	000402026400013
EID SCOPUS	85017344151
DOI	10.1016/j.nlm.2017.03.018
Annotation	Adult neurogenesis in the dentate gyrus adds a substantial number of new functional neurons to the hippocampus network in rodents. To date, however, the function of these new granule cells remains unclear. We conducted an experiment to assess the contribution of adult neurogenesis in the dentate gyrus to acquisition and reversal learning in a task that predominantly requires generalization of a rule. Young adult male Long-Evans rats were repeatedly administered either a cytostatic temozolomide or saline for a period of four weeks (3 injections per week). Post treatment, animals were injected with bromodeoxyuridine to quantify adult neurogenesis in the dentate gyrus. For behavioral assessment we used hippocampus-dependent active place avoidance with reversal in a Carousel maze. Animals first learned to avoid a 60° sector on the rotating arena. Afterwards, sector was relocated to the opposite side of the rotating arena (reversal). The administration of temozolomide significantly improved the reversal performance compared to saline-treated rats. Our results suggest a significant, level-dependent, improvement of reversal learning in animals with reduced adult neurogenesis in hippocampus.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2018

Number of the records: 1