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Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario
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SYSNO ASEP 0458559 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario Author(s) Šponer, Judit E. (BFU-R) RID, ORCID
Šponer, Jiří (BFU-R) RID, ORCID
Nováková, Olga (BFU-R) RID, ORCID
Brabec, Viktor (BFU-R) RID, ORCID
Šedo, O. (CZ)
Zdráhal, Z. (CZ)
Costanzo, G. (IT)
Pino, S. (IT)
Saladino, R. (IT)
Di Mauro, E. (IT)Number of authors 10 Source Title Chemistry - A European Journal. - : Wiley - ISSN 0947-6539
Roč. 22, č. 11 (2016), s. 3572-3586Number of pages 15 s. Publication form Print - P Language eng - English Country DE - Germany Keywords formamide ; nucleobases ; nucleotides Subject RIV BO - Biophysics R&D Projects GA14-12010S GA ČR - Czech Science Foundation (CSF) GA13-08273S GA ČR - Czech Science Foundation (CSF) GBP206/12/G151 GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000371741400009 DOI 10.1002/chem.201503906 Annotation 50years after the historical Miller-Urey experiment, the formamide-based scenario is perhaps the most powerful concurrent hypothesis for the origin of life on our planet besides the traditional HCN-based concept. The information accumulated during the last 15years in this topic is astonishingly growing and nowadays the formamide-based model represents one of the most complete and coherent pathways leading from simple prebiotic precursors up to the first catalytically active RNA molecules. In this work, we overview the major events of this long pathway that have emerged from recent experimental and theoretical studies, mainly concentrating on the mechanistic, methodological, and structural aspects of this research. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2017
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