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TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms
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SYSNO ASEP 0435671 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms Author(s) Uchytilová, Eva (FGU-C)
Špicarová, Diana (FGU-C) RID, ORCID
Paleček, Jiří (FGU-C) RID, ORCIDSource Title Molecular Pain
Roč. 10, č. 2014 (2014), s. 67Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords SB366791 ; TRPV1 ; allodynia ; hyperalgesia ; surgical pain ; spinal cord Subject RIV FH - Neurology R&D Projects EE2.3.30.0025 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) LH12058 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GPP303/12/P510 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000350453100001 EID SCOPUS 84925286055 DOI 10.1186/1744-8069-10-67 Annotation Acute postoperative pain is one of the frequent reasons for pain treatment. However, the exact mechanisms of its development are still not completely clear. Transient receptor potential vanilloid 1 (TRPV1) receptors are involved in nociceptive signaling in various hypersensitive states. Here we have investigated the contribution of TRPV1 receptors expressed on cutaneous peripheral nociceptive fibers and in the spinal cord on the development and maintenance of hypersensitivity to thermal and mechanical stimuli following surgical incision. A rat plantar incision model was used to test paw withdrawal responses to thermal and mechanical stimuli. The effect of the TRPV1 receptor antagonist SB366791 was investigated 1) by intrathecal injection 15 min before incision and 2) intradermal injection before (30 min) and immediately after the surgery. Vehicle-injected rats and naïve animals treated identically were used as controls Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
Number of the records: 1