Chiral separability of boron cluster species studied by screening approaches utilizing polysaccharide-based chiral stationary phases

0428338 - BFÚ 2015 RIV GB eng J - Journal Article
Mangelings, D. - Vander Heyden, Y. - Vespalec, Radim
Chiral separability of boron cluster species studied by screening approaches utilizing polysaccharide-based chiral stationary phases.
Biomedical Chromatography. Roč. 28, č. 5 (2014), s. 694-707. ISSN 0269-3879. E-ISSN 1099-0801
Institutional support: RVO:68081707
Keywords : SUPERCRITICAL-FLUID CHROMATOGRAPHY * ORGANIC-SOLVENT CHROMATOGRAPHY * LIQUID-CHROMATOGRAPHY
Subject RIV: BO - Biophysics
Impact factor: 1.723, year: 2014

In this study, the screening steps of chiral separation strategies with polysaccharide-based chiral stationary phases were applied on boron cluster compounds in normal-phase liquid chromatography (NPLC) and polar organic solvents chromatography (POSC). Since the screening steps were initially developed to analyze organic compounds, their applicability for boron clusters was investigated. Overall, the screening steps in NPLC were applicable for the separation of zwitterions, while for anions mostly no elution was observed. A hypothesis for the latter behavior is precipitation of anions in the nonpolar mobile phases. Ten out of 11 compounds could be partially or baseline separated on the NPLC screening systems. In POSC, all zwitterions were separated on at least one of the screening systems, with an overall lower retention as in NPLC. Anions were detected but not separated in the majority of the experiments. Also their retention on the chiral stationary phases was very limited.
Permanent Link: http://hdl.handle.net/11104/0233697