Age- and Sex-Dependent Effects of Ethanol on Hippocampal Hemicholinum-3 Sensitive Choline Carriers during Postnatal Development of Rats

0404883 - UIVT-O 20030031 RIV US eng J - Journal Article
Krištofíková, Z. - Platilová, V. - Klaschka, Jan
Age- and Sex-Dependent Effects of Ethanol on Hippocampal Hemicholinum-3 Sensitive Choline Carriers during Postnatal Development of Rats.
Neurochemical Research. Roč. 28, 3/4 (2003), s. 397-405. ISSN 0364-3190. E-ISSN 1573-6903
Institutional research plan: AV0Z1030915
Keywords : ethanol * high-affinity transport * hemicholinium-3 * postnatal development * hippocampus
Subject RIV: BB - Applied Statistics, Operational Research
Impact factor: 1.511, year: 2003

Vulnerability of hippocampal hemicholinium-3 (HC-3) sensitive carriers to ethanol was evaluated in vitro during rat postnatal development. The high-affinity uptake of (3H)choline (HACU) and the specific binding of (3H)HC-3 were measured in 7-, 14-, 60-day and 3-month old male and female rats. Both age- and sex-dependent alterations in basal HACU mediated by alcohol were observed in the immature tissue. Our results suggest the noncompetitive binding of alcohol to choline carriers from immature male tissue.
Permanent Link: http://hdl.handle.net/11104/0125108