Number of the records: 1
Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles
- 1.0397537 - FGÚ 2014 RIV US eng J - Journal Article
Sládek, Martin - Sumová, Alena
Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles.
PLoS ONE. Roč. 8, č. 10 (2013), e77010. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GPP305/10/P244; GA ČR(CZ) GAP303/11/0668
Institutional support: RVO:67985823
Keywords : circadian rhythms * temperature * entrainment * SHR * fibroblasts * phase response curve
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.534, year: 2013
We showed that two consecutive square-wave temperature cycles with amplitudes of 2.5°C are with similar efficiency able to restart damped oscillations and entrain the circadian clock in fibroblasts derived from both spontaneously hypertensive rat and control Wistar rat. We described phase response curves to temperature cycles for fibroblast clock from both strains and concluded that despite slight resistance of SHR cells to temperature entrainment, the overall effect is too weak to be responsible for SHR circadian phenotype in vivo
Permanent Link: http://hdl.handle.net/11104/0225203
Number of the records: 1