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Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity
- 1.0397105 - ÚEM 2014 RIV GB eng J - Journal Article
Wang, T. - Rusu, S. I. - Hrušková, Bohdana - Tureček, Rostislav - Borst, J. G.
Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity.
Journal of Physiology. Roč. 591, č. 19 (2013), s. 4877-4894. ISSN 0022-3751. E-ISSN 1469-7793
R&D Projects: GA ČR(CZ) GAP303/11/0131
Institutional support: RVO:68378041
Keywords : GABAB * synaptic transmission * auditory
Subject RIV: FH - Neurology
Impact factor: 4.544, year: 2013
The calyx of Held synapse of the medial nucleus of the trapezoid body is a giant axosomatic synapse in the auditory brainstem, which acts as a relay synapse showing large number of release sites with low release probability. We investigated the contribution of presynaptic GABAB receptors and spontaneous activity to release probability both in vivo and in vitro in young-adult mice. Our data thus suggest that spontaneous firing can tonically reduce release probability in vivo. In addition, our data show that the ambient GABA concentration in the auditory brainstem is too low to activate the GABAB receptor at the calyx of Held significantly, but that activation of GABAB receptors can reduce sound-evoked synaptic depression. key words (3): GABAB, synaptic transmission, auditory
Permanent Link: http://hdl.handle.net/11104/0224748
Number of the records: 1