Number of the records: 1
Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt
- 1.0392596 - FGÚ 2014 RIV CH eng J - Journal Article
Wasková-Arnoštová, P. - Elsnicová, B. - Kašparová, D. - Šebesta, O. - Novotný, J. - Neckář, Jan - Kolář, František - Žurmanová, J.
Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt.
Cellular Physiology and Biochemistry. Roč. 31, č. 1 (2013), s. 66-79. ISSN 1015-8987
R&D Projects: GA AV ČR(CZ) IAAX01110901
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : hexokinase isoforms * akt kinase * left ventricle * right ventricle * mitochondria co-localization
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 3.550, year: 2013
The purpose of this study was to investigate expression and subcellular localization of both HK isoforms in left (LV) and right (RV) heart ventricles of adult male Wistar rats. Our results showed a significantly higher expression of both HK1 and HK2 at mRNA and protein levels in the RV compared to the LV. These results suggest that the RV has a higher activity of aerobic glycolytic metabolism and may be able to respond faster and more powerfully to stressful stimuli than the LV
Permanent Link: http://hdl.handle.net/11104/0221432
Number of the records: 1