PEG chains increase aspermatogenic and antitumor activity of RNase A and BS-RNase enzymes

0213433 - UZFG-Y 20023045 RIV NL eng J - Journal Article
Matoušek, Josef - Poučková, P. - Souček, J. - Škvor, J.
PEG chains increase aspermatogenic and antitumor activity of RNase A and BS-RNase enzymes.
Journal of Controlled Release. Roč. 82, - (2002), s. 29-37. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR GA523/01/0114; GA AV ČR KSK5052113
Keywords : antitumor * aspermatogenesis * BS-RNase
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.131, year: 2002

The experiments proved that RNase A, when conjugated to PEG, produced identical aspermatogenic and antitumour effects as BS-RNase conjugated to this polymer.Immunogenicity of RNase A and BS-RNase did not change substantially after the conjugation with PEG polymers. Binding of produced antibodies to both ribonucleases attached to PEG, however, was substantially reduced.
Permanent Link: http://hdl.handle.net/11104/0108970