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Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats
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SYSNO ASEP 0142120 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats Author(s) Pravenec, Michal (FGU-C) RID, ORCID
Landa, Vladimír (UMG-J)
Zídek, Václav (FGU-C) RID
Musilová, Alena (FGU-C)
Křen, Vladimír (FGU-C)
Kazdová, L. (CZ)
Aitman, T. J. (GB)
Glazier, A. M. (GB)
Ibrahimi, A. (US)
Abumrad, N. A. (US)
Qi, N. (US)
Wang, J. M. (US)
St.Lezin, E. M. (US)
Kurtz, W. T. (US)Source Title Nature Genetics. - : Nature Publishing Group - ISSN 1061-4036
Roč. 27, č. 2 (2001), s. 156-158Number of pages 3 s. Language eng - English Country US - United States Keywords Cd36 (fatty acid transporter) Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/00/1636 GA ČR - Czech Science Foundation (CSF) GV204/98/K015 GA ČR - Czech Science Foundation (CSF) LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5011922 - FGU-C Annotation We found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2002
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