Number of the records: 1  

Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

  1. 1.
    SYSNO ASEP0142120
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JOstatní články
    TitleTransgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats
    Author(s) Pravenec, Michal (FGU-C) RID, ORCID
    Landa, Vladimír (UMG-J)
    Zídek, Václav (FGU-C) RID
    Musilová, Alena (FGU-C)
    Křen, Vladimír (FGU-C)
    Kazdová, L. (CZ)
    Aitman, T. J. (GB)
    Glazier, A. M. (GB)
    Ibrahimi, A. (US)
    Abumrad, N. A. (US)
    Qi, N. (US)
    Wang, J. M. (US)
    St.Lezin, E. M. (US)
    Kurtz, W. T. (US)
    Source TitleNature Genetics. - : Nature Publishing Group - ISSN 1061-4036
    Roč. 27, č. 2 (2001), s. 156-158
    Number of pages3 s.
    Languageeng - English
    CountryUS - United States
    KeywordsCd36 (fatty acid transporter)
    Subject RIVEB - Genetics ; Molecular Biology
    R&D ProjectsGA301/00/1636 GA ČR - Czech Science Foundation (CSF)
    GV204/98/K015 GA ČR - Czech Science Foundation (CSF)
    LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    CEZAV0Z5011922 - FGU-C
    AnnotationWe found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2002

Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.