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Role of GSTT1 deletion in DNA oxidative damage by exposure to polycyclic aromatic hydrocarbons in humans
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SYSNO ASEP 0087539 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Role of GSTT1 deletion in DNA oxidative damage by exposure to polycyclic aromatic hydrocarbons in humans Title Úloha delece v genu GSTT1 v oxidačním poškození DNA při expozici osob polycyklickým aromatickým uhlovodíkům Author(s) Garte, S. (IT)
Taioli, E. (IT)
Popov, T. (BG)
Kalina, I. (SK)
Šrám, Radim (UEM-P) RID
Farmer, P. (GB)Source Title International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 120, - (2007), s. 2499-2503Number of pages 5 s. Language eng - English Country DE - Germany Keywords metabolic polymorphism ; GSTT1 genotype ; oxidative DNA damage Subject RIV DN - Health Impact of the Environment Quality Next source Framework programmes of European Commission CEZ AV0Z50390512 - UEM-P (2005-2011) Annotation The genotype data at the GSTT and other loci are analyzed to try to understand the role of certain common metabolic genotypes in the variability of response among human beings to the genotoxic effects of PAH exposure. The results support the hypothesis that the GSTT genetic variant plays a role in mediating toxic effects from PAH exposures (in protecting oxidative DNA damage). Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2008
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