Modelling the cardiac transverse-axial tubular system

0087221 - ÚT 2008 RIV GB eng J - Journal Article
Pásek, Michal - Šimurda, J. - Christé, G. - Orchard, C.
Modelling the cardiac transverse-axial tubular system.
[Modelování transverzálně-axiálního tubulárního systému u srdečních buněk.]
Progress in Biophysics & Molecular Biology. Roč. 96, - (2008), s. 226-246. ISSN 0079-6107. E-ISSN 1873-1732
Institutional research plan: CEZ:AV0Z20760514
Keywords : cardiac cell * transverse-axial tubular system * quantitative modelling
Subject RIV: BO - Biophysics
Impact factor: 6.388, year: 2008

The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure?

Práce shrnuje nejnovější výsledky výpočtového modelování funkce transverzálně-axiálního tubulárního systému u srdečních komorových buněk a vytyčuje nové otázky ve výzkumu jeho fyziologické role.
Permanent Link: http://hdl.handle.net/11104/0149122