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Effect of spironolactone and captopril on nitric oxide and S-nitrosothiol formation in kidney of L-NAME-treated rats
- 1.0049951 - FGÚ 2007 RIV US eng J - Journal Article
Pecháňová, Olga - Matušková, J. - Čapíková, D. - Jendeková, L. - Paulis, L. - Šimko, F.
Effect of spironolactone and captopril on nitric oxide and S-nitrosothiol formation in kidney of L-NAME-treated rats.
[Účinek spironolaktonu a kaptoprilu na tvorbu oxidu dusnatého a S-nitrosothiolů v ledvinách potkanů s L-NAME hypertenzí.]
Kidney International. Roč. 70, č. 1 (2006), s. 170-176. ISSN 0085-2538. E-ISSN 1523-1755
Grant - others:VEGA(SK) 2/6148/26; VEGA(SK) 1/3429/06; SAV(SK) APVT51-027404
Institutional research plan: CEZ:AV0Z50110509
Keywords : captopril * spironolactone * L-NAME hypertension
Subject RIV: ED - Physiology
Impact factor: 4.773, year: 2006
Both captopril and spironolactone prevented L-NAME-induced hypertension and the decline of the antioxidant potential of the kidney tissue. However, only spironolactone improved NO synthase activity which led to the S-nitrosothiols formation. Both NO itself and S-nitrosothiols may contribute to the preventive effect of spironolactone against development of L-NAME-induced hypertension
Jak kaptopril tak spironolakton zabraňují vzniku L-NAME hypertenze a snižují oxidační potenciál v tkáních ledviny. Pouze spironolakton zvýšil aktivitu NO syntázy a tvorbu S-nitrosothiolů. Jak samotný NO tak i S-nitrosothioly přispívají k preventivním účinkům spironolaktonu proti vzniku L-NAME hypertenze
Permanent Link: http://hdl.handle.net/11104/0140217
Number of the records: 1