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MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
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SYSNO ASEP 0618502 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration Author(s) Zdouc, M. M. (NL)
Blin, K. (DK)
Louwen, N. L. L. (NL)
Navarro, J. (NL)
Loureiro, C. (NL)
Bader, C. D. (DE)
Bailey, C. B. (AU)
Barra, L. (DE)
Booth, T. J. (DK)
Bozhueyuek, K. A. J. (DE)
Cediel-Becerra, J. D. D. (US)
Charlop-Powers, Z. (US)
Chevrette, M. G. (US)
Chooi, Y. H. (AU)
D'Agostino, P. M. (DE)
de Rond, T. (NZ)
Del Pup, E. (NL)
Duncan, K. R. (GB)
Gu, W. (US)
Hanif, N. (ID)
Helfrich, E. J. N. (DE)
Jenner, M. (GB)
Katsuyama, Y. (JP)
Korenskaia, A. (DE)
Krug, D. (DE)
Damiani, Tito (UOCHB-X) ORCID
Hebra, Téo (UOCHB-X) ORCID
Sehnal, L. (CZ)
Weber, T. (DE)
Medema, M. H. (NL)Source Title Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
Roč. 53, č. 1 (2025), D678-D690Number of pages 13 s. Language eng - English Country US - United States R&D Projects EH22_010/0002733 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 UT WOS 001443163100002 EID SCOPUS 85214414411 DOI https://doi.org/10.1093/nar/gkae1115 Annotation Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2026 Electronic address https://doi.org/10.1093/nar/gkae1115
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