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Schistosomiasis at the Crossroad to Elimination: Review of Eclipsed Research with Emphasis on the Post-Transmission Agenda
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SYSNO ASEP 0557052 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Schistosomiasis at the Crossroad to Elimination: Review of Eclipsed Research with Emphasis on the Post-Transmission Agenda Author(s) Giboda, Michal (BC-A) RID, ORCID
Bergquist, R. (SE)
Utzinger, J. (CH)Number of authors 3 Article number 55 Source Title Tropical Medicine and Infectious Disease. - : MDPI
Roč. 7, č. 4 (2022)Number of pages 17 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords mansoni eggs ; puerto-rico ; praziquantel ; diagnosis ; prevalence ; japonicum ; poliomyelitis ; resistance ; children ; antigen ; acute schistosomiasis ; chronic schistosomiasis ; egg-induced pathology ; elimination ; persisting disease ; post-transmission schistosomiasis Subject RIV FP - Other Medical Disciplines OECD category Parasitology Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000785061200001 EID SCOPUS 85128470202 DOI https://doi.org/10.3390/tropicalmed7040055 Annotation While chronic schistosomiasis is pathologically well defined, the acute form of the disease is less well understood. It is generally agreed that early lesions, such as lung nodules and bladder polyps, are reversible, which impedes identification of the time elapsed since exposure. The intermediate stage between the acute and the chronic forms of schistosomiasis requires further investigation, as does the clinical stage due to lesions remaining after treatment. With current schistosomiasis control efforts gradually progressing to elimination, there is a need to focus on post-transmission schistosomiasis, which not only refers to remaining lesions from previous infections, but also accounts for the potential presence of surviving worms after treatment. This issue is particularly salient for migrants from endemic to non-endemic countries and should be kept in mind for returning expatriates from schistosomiasis-endemic countries. Negative stool examination or urine filtration are generally taken as indicative of cure since rectoscopy for Schistosoma mansoni infection, or cystoscopy for S. haematobium infection, are rarely performed. However, pathology of affected organs may persist indefinitely, while potentially remaining live worms could produce additional pathology. Hence, post-transmission schistosomiasis can prevail for years after elimination of the disease, and thus, warrant further attention. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2023 Electronic address https://www.mdpi.com/2414-6366/7/4/55
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