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Genetically modified cellular vaccines against human papillomavirus type 16 (HPV16)-associated tumors: adjuvant treatment of minimal residual disease after surgery/chemotherapy
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SYSNO ASEP 0346751 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetically modified cellular vaccines against human papillomavirus type 16 (HPV16)-associated tumors: adjuvant treatment of minimal residual disease after surgery/chemotherapy Author(s) Bubeník, Jan (UMG-J)
Šímová, Jana (UMG-J) RIDSource Title Journal of Balkan Union of Oncology - ISSN 1107-0625
Roč. 14, č. 1 (2009), s. 169-173Number of pages 5 s. Language eng - English Country GR - Greece Keywords residual tumour disease ; HPV16 ; cellular vaccines Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/06/0774 GA ČR - Czech Science Foundation (CSF) GA301/07/1410 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000270421500021 Annotation Local recurrences at the site of tumour resection or after chemotherapy, as well as distant micrometastases represent major problems in oncology. Genetically modified cellular vaccines were found to be efficient against cancer both in experimental models and in tumour-bearing patients. It was also shown in various systems that the efficacy of conventional therapeutic modalities can be supported by adjuvant administration of genetically modified vaccines, as well as by depletion of immunosuppressive immunocyte subsets. The purpose of this review is to summarize and evaluate the results obtained with administration of genetically modified cellular vaccines as well as with depletion of immunosuppressive immunocytes performed as treatment of the minimal residual tumour disease after surgery / chemotherapy in the experimental model of murine tumours mimicking human HPV 16-associated neoplasms. The prospects and limitations of these adjuvant immunotherapeutic modalities will be discussed. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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