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Radiobiology Textbook
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SYSNO ASEP 0602845 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities Author(s) Ahire, V. (CN)
Ahmadi Bidakhvidi, N. (BE)
Boterberg, T. (BE)
Chaudhary, P. (GB)
Chevalier, F. (FR)
Daems, N. (BE)
Delbart, W. (BE)
Baatout, S. (BE)
Deroose, C. M. (BE)
Fernandez-Palomo, C. (CH)
Franken, N. A. P. (NL)
Gaipl, U. S. (DE)
Geenen, L. (BE)
Heynickx, N. (BE)
Koniarová, I. (CZ)
Selvaraj, V. K. (IN)
Levillain, H. (BE)
Jelínek Michaelidesová, Anna (UJF-V) RID, ORCID, SAI
Montoro, A. (ES)
Oei, A. L. (NL)
Penninckx, S. (BE)
Reindl, J. (DE)
Rödel, F. (DE)
Sminia, P. (NL)
Tabury, K. (US)
Vermeulen, K. (BE)
Viktorsson, K. (SE)
Waked, A. (BE)Number of authors 28 Source Title Radiobiology Textbook. - Cham : Springer Nature Switzerland AG, 2023 / Baatout S. - ISBN 978-3-031-18809-1 Pages s. 311-386 Number of pages 76 s. Number of copy 200 Number of pages 666 Publication form Print - P Language eng - English Country CH - Switzerland Keywords Clinical radiotherapy ; Combination therapy ; High LET particles ; Nanoparticles ; Radionuclide therapy ; Stereotactic Body Radiation Therapy OECD category Radiology, nuclear medicine and medical imaging Institutional support UJF-V - RVO:61389005 EID SCOPUS 85180525388 DOI https://doi.org/10.1007/978-3-031-18810-7_6 Annotation In this chapter, we address the role of radiation as treatment modality in the context of oncological treatments given to patients. Physical aspects of the use of ionizing radiation (IR)-by either photons, neutrons, or charged (high linear energy transfer) particles-and their clinical application are summarized. Information is also provided regarding the radiobiological rationale of the use of conventional fractionation as well as alternative fractionation schedules using deviating total dose, fraction size, number of fractions, and the overall treatment time. Pro-and contra arguments of hypofractionation are discussed. In particular, the biological rationale and clinical application of Stereotactic Body Radiation Therapy (SBRT) are described. Furthermore, background information is given about FLASH radiotherapy (RT), which is an emerging new radiation method using ultra-high dose rate allowing the healthy, normal tissues and organs to be spared while maintaining the antitumor effect. Spatial fractionation of radiation in tumor therapy, another method that reduces damage to normal tissue is presented. Normal tissue doses could also be minimized by interstitial or intraluminal irradiation, i.e., brachytherapy, and herein an overview is given on the principles of brachytherapy and its clinical application. Furthermore, details are provided regarding the principles, clinical application, and limitations of boron neutron capture therapy (BNCT). Another important key issue in cancer therapy is the combination of RT with other treatment modalities, e.g., chemotherapy, targeted therapy, immunotherapy, hyperthermia, and hormonal therapy. Combination treatments are aimed to selectively enhance the effect of radiation in cancer cells or to trigger the immune system but also to minimize adverse effects on normal cells. The biological rationale of all these combination treatments as well as their application in clinical settings are outlined. To selectively reach high concentrations of radionuclides in tumor tissue, radioembolization is a highly interesting approach. Also, radioligand therapy which enables specific targeting of cancer cells, while causing minimal harm surrounding healthy tissues is presented. A brief overview is provided on how nanotechnology could contribute to the diagnosis and treatment of cancer. Last but not least, risk factors involved in acquiring secondary tumors after RT are discussed. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2025 Electronic address https://link.springer.com/chapter/10.1007/978-3-031-18810-7_6
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