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Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion
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SYSNO ASEP 0602502 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion Author(s) Montes, P. (CZ)
Chopra, Tania (UMCH-V) ORCID
Konefal, Rafal (UMCH-V) RID, ORCID
Hájovská, P. (SK)
Lacík, I. (SK)
Raus, Vladimír (UMCH-V) RID, ORCID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Uchman, M. (CZ)
Štěpánek, M. (CZ)Source Title Soft Matter - ISSN 1744-683X
Roč. 20, č. 47 (2024), s. 9475-9482Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords interpolyelectrolyte complex ; polycation ; nanoparticles Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LM2023053 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 001359741600001 EID SCOPUS 85209707594 DOI https://doi.org/10.1039/D4SM00851K Annotation Biguanide-based cationic polyelectrolytes are used as key components of interpolyelectrolyte complexes bolstering alginate hydrogel microcapsules employed in cell therapies. Nevertheless, electrostatic complexation of these unique polycations has not been studied before. In this study, the interaction between biguanide condensates and anionic polyelectrolytes with carboxylate groups was studied on a model system of a metformin condensate (MFC) and an anionic diblock polyelectrolyte poly(methacrylic acid)-block-poly(ethylene oxide) (PMAA–PEO). The formation of MFC/PMAA–PEO core–corona nanoparticles was followed by static, dynamic and electrophoretic light scattering and by isothermal titration calorimetry and their internal structure was investigated by small angle neutron scattering and cryogenic transmission electron microscopy. It was found that the aggregation of PMAA–PEO chains induced by MFC occurred at much lower MFC/PMAA–PEO ratios that would correspond to the isoelectric point, thus yielding strongly negatively charged nanoparticles, suggesting the role of specific (non-electrostatic) interactions in the stabilization of the complex between PMAA and MFC. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2025 Electronic address https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00851k
Number of the records: 1