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The deletion of AQP4 and TRPV4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies
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SYSNO ASEP 0585938 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The deletion of AQP4 and TRPV4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies Author(s) Heřmanová, Zuzana (UEM-P) ORCID
Valihrach, Lukáš (UEM-P)
Kriška, Ján (UEM-P) RID, ORCID
Maheta, M. (CZ)
Turečková, Jana (UEM-P) ORCID
Kubista, M. (CZ)
Anděrová, Miroslava (UEM-P) RID, ORCIDArticle number 1393751 Source Title Frontiers in Cellular Neuroscience. - : Frontiers Media - ISSN 1662-5102
Roč. 18, May (2024)Number of pages 22 s. Language eng - English Country CH - Switzerland Keywords aquaporin 4 ; transient receptor potential vanilloid 4 ; astrocytes ; brain edema ; ischemia OECD category Neurosciences (including psychophysiology R&D Projects GA20-05770S GA ČR - Czech Science Foundation (CSF) LX22NPO5107 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2023050 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 001233868900001 EID SCOPUS 85194839499 DOI https://doi.org/10.3389/fncel.2024.1393751 Annotation Astrocytic Transient receptor potential vanilloid 4 (TRPV4) channels, together with Aquaporin 4 (AQP4), are suspected to be the key players in cellular volume regulation, and therefore may affect the development and severity of cerebral edema during ischemia. In this study, we examined astrocytic swelling/volume recovery in mice with TRPV4 and/or AQP4 deletion in response to in vitro ischemic conditions, to determine how the deletion of these channels can affect the development of cerebral edema. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2025 Electronic address https://www.frontiersin.org/articles/10.3389/fncel.2024.1393751/full
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