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The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
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SYSNO ASEP 0585453 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis Author(s) Raspopović, A. B. (HR)
Balta, V. (HR)
Vodopić, M. (HR)
Drobac, M. (HR)
Boroš, Almoš (FGU-C) RID, ORCID
Dikić, D. (HR)
Demarin, V. (HR)Article number 20240952 Source Title Open Medicine - ISSN 2391-5463
Roč. 19, č. 1 (2024)Number of pages 8 s. Language eng - English Country PL - Poland Keywords glutathione ; oxidative stress ; multiple sclerosis ; MoCA test OECD category Cardiac and Cardiovascular systems Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001199884500001 EID SCOPUS 85190355859 DOI https://doi.org/10.1515/med-2024-0952 Annotation Oxidative stress markers have a distinct role in the process of demyelination in multiple sclerosis. This study investigated the potential correlation of markers of oxidative stress (glutathione [GSH], catalase) with the number of demyelinating lesions and the degree of disability, cognitive deficit, and depression in patients with relapsing-remitting multiple sclerosis (RRMS). Sixty subjects meeting the criteria for RRMS (19 men and 41 women), and 66 healthy controls (24 men, 42 women) were included. In this study, GSH significantly negatively correlated with the degree of cognitive impairment. This is the first study of subjects with RRMS that performed the mentioned research of serum GSH levels on the degree of cognitive damage examined by the Montreal Scale of Cognitive Assessment (MoCA) test. The development of cognitive changes, verified by the MoCA test, was statistically significantly influenced by the positive number of magnetic resonance lesions, degree of depression, expanded disability status scale (EDSS), age, and GSH values. Based on these results, it can be concluded that it is necessary to monitor cognitive status early in RRMS patients, especially in those with a larger number of demyelinating lesions and a higher EDSS level and in older subjects. Also, the serum level of GSH is a potential biomarker of disease progression, which could be used more widely in RRMS. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2025 Electronic address https://doi.org/10.1515/med-2024-0952
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