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PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma
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SYSNO ASEP 0585208 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma Author(s) Přibyl, T. (CZ)
Rumlová, M. (CZ)
Mikyšková, Romana (UMG-J) RID
Reiniš, Milan (UMG-J) RID
Kaňa, A. (CZ)
Škoch, Karel (UACH-T) SAI, ORCID, RID
Zelenka, J. (CZ)
Kirakci, Kaplan (UACH-T) SAI, RID, ORCID
Ruml, T. (CZ)
Lang, Kamil (UACH-T) SAI, RID, ORCIDNumber of authors 10 Source Title Inorganic Chemistry. - : American Chemical Society - ISSN 0020-1669
Roč. 63, č. 9 (2024), s. 4419-4428Number of pages 10 s. Language eng - English Country US - United States Keywords induced photodynamic therapy ; cluster complexes ; cancer ; nanoparticles ; luminescence ; (mo6i8)(4+) OECD category Cell biology R&D Projects GA21-11688S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMG-J - RVO:68378050 ; UACH-T - RVO:61388980 UT WOS 001166802200001 EID SCOPUS 85186243334 DOI 10.1021/acs.inorgchem.4c00084 Annotation The combination of photodynamic therapy and radiotherapy has given rise to a modality called radiodynamic therapy (RDT), based on reactive oxygen species-producing radiosensitizers. The production of singlet oxygen, O-2((1)Delta(g)), by octahedral molybdenum (Mo-6) clusters upon X-ray irradiation allows for simplification of the architecture of radiosensitizing systems. In this context, we prepared a radiosensitizing system using copper-free click chemistry between a Mo-6 cluster bearing azido ligands and the homo-bifunctional linker bis-dPEG(11)-DBCO. The resulting compound formed nanoparticles, which featured production of O-2((1)Delta(g)) and efficient cellular uptake, leading to remarkable photo- and radiotoxic effects against the prostatic adenocarcinoma TRAMP-C2 cell line. Spheroids of TRAMP-C2 cells were also used for evaluation of toxicity and phototoxicity. In vivo experiments on a mouse model demonstrated that subcutaneous injection of the nanoparticles is a safe administration mode at a dose of up to 0.08 g kg(-1). The reported results confirm the relevancy of Mo-6-based radiosensitizing nanosystems for RDT. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2025 Electronic address https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c00084
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