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Dimetindene-Is the minimum toxic dose for children too strict?
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SYSNO ASEP 0584870 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dimetindene-Is the minimum toxic dose for children too strict? Author(s) Čečrle, M. (CZ)
Pelclová, D. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Zacharov, S. (CZ)Source Title Basic & Clinical Pharmacology & Toxicology. - : Wiley - ISSN 1742-7835
Roč. 134, č. 5 (2024), s. 750-755Number of pages 6 s. Language eng - English Country US - United States Keywords toxicological information-center ; medication errors ; children poisoning ; dimetindene ; sedating antihistamines ; toxic dose Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Method of publishing Limited access Institutional support UFCH-W - RVO:61388955 UT WOS 001189182500001 EID SCOPUS 85189154340 DOI 10.1111/bcpt.14005 Annotation Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16.5%) were excluded because of uncertain ingestion. In 116 children (46 boys and 70 girls, mean age 2 years and 9 months +/- 1 year and 1 month), the majority of children developed no symptoms (87 children, 75%, mean age 3 years +/- 1 year) and the remaining 29 children (25%, mean age 2 years and 11 months +/- 1 year and 3 months) developed only mild and spontaneously resolving symptoms of poisoning after a dose of 0.82 +/- 0.32 mg/kg b.w. (range 0.26-1.82 mg/kg). In 98% of all cases, hospitalized children were observed for a maximum 24 h, and their condition did not require specific treatment. In conclusion, the prognosis for accidental dimetindene poisoning in children appears to be good and the minimum toxic dose has been determined to be 0.5 mg/kg b.w. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2025 Electronic address https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14005
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