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High Dose Fish Oil Added to Various Lipid Emulsions Normalizes Superoxide Dismutase 1 Activity in Home Parenteral Nutrition Patients
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SYSNO ASEP 0584090 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title High Dose Fish Oil Added to Various Lipid Emulsions Normalizes Superoxide Dismutase 1 Activity in Home Parenteral Nutrition Patients Author(s) Ševela, S. (CZ)
Meisnerová, E. (CZ)
Vecka, M. (CZ)
Vávrová, J. (CZ)
Rychlíková, J. (CZ)
Leníček, M. (CZ)
Vítek, L. (CZ)
Nováková, Olga (FGU-C)
Novák, F. (CZ)Number of authors 9 Article number 485 Source Title Nutrients. - : MDPI
Roč. 16, č. 4 (2024)Number of pages 14 s. Language eng - English Country CH - Switzerland Keywords chronic intestinal failure ; short bowel syndrome ; oxidative stress ; fibroblast growth factor 19 ; liver function tests ; bile acids OECD category Cardiac and Cardiovascular systems Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001172585700001 EID SCOPUS 85185944188 DOI 10.3390/nu16040485 Annotation (1) Objectives: Intestinal failure in home parenteral nutrition patients (HPNPs) results in oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to various lipid emulsions influences antioxidant status and liver function markers in HPNPs. (2) Methods: Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. Then, the patients were randomized to subsequently receive Lipoplus and ClinOleic for 6 weeks or vice versa plus 4 weeks of Omegaven after each cycle in a crossover design. Twelve age- and sex-matched healthy controls (HCs) were included. (3) Results: Superoxide dismutase (SOD1) activity and oxidized-low-density lipoprotein concentration were higher in all baseline HPN regimens compared to HCs. The Omegaven lowered SOD1 compared to baseline regimens and thus normalized it toward HCs. Lower paraoxonase 1 activity and fibroblast growth factor 19 (FGF19) concentration and, on the converse, higher alkaline phosphatase activity and cholesten concentration were observed in all baseline regimens compared to HCs. A close correlation was observed between FGF19 and SOD1 in baseline regimens. (4) Conclusions: An escalated dose of FO normalized SOD1 activity in HPNPs toward that of HCs. Bile acid metabolism was altered in HPNPs without signs of significant cholestasis and not affected by Omegaven. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2025 Electronic address https://www.mdpi.com/2072-6643/16/4/485
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