Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review

Šuca, H.; Čoma, M.; Tomšů, Júlia; Sabová, J.; Zajíček, R.; Brož, Antonín; Doubková, Martina; Novotný, T.; Bačáková, Lucie; Jenčová, V.; Kuželová Košťáková, E.; Lukačín, Š.; Rejman, Dominik; Gál, P.

doi:https://dx.doi.org/10.1016/j.jss.2023.12.043

Number of the records: 1

Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review

1.

SYSNO ASEP	0583345
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review
Author(s)	Šuca, H. (CZ) Čoma, M. (SK) Tomšů, Júlia (FGU-C) Sabová, J. (SK) Zajíček, R. (CZ) Brož, Antonín (FGU-C)_{RID, ORCID, SAI} Doubková, Martina (FGU-C)_{ORCID, RID} Novotný, T. (CZ) Bačáková, Lucie (FGU-C)_{RID, ORCID} Jenčová, V. (CZ) Kuželová Košťáková, E. (CZ) Lukačín, Š. (SK) Rejman, Dominik (UOCHB-X)_{RID, ORCID} Gál, P. (CZ)
Source Title	Journal of Surgical Research. - : Elsevier - ISSN 0022-4804 Roč. 296, April (2024), s. 383-403
Number of pages	21 s.
Language	eng - English
Country	NL - Netherlands
Keywords	regeneration ; scar ; skin ; wound dressing ; wound healing
OECD category	Cell biology
R&D Projects	NU22-06-00016 GA MZd - Ministry of Health (MZ)
	LX22NPO5103 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA22-08857S GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823 ; UOCHB-X - RVO:61388963
UT WOS	001182164100001
EID SCOPUS	85185179580
DOI	10.1016/j.jss.2023.12.043
Annotation	Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue to result in socioeconomic burdens for victims and their families. The management of severe burn injuries involves preventing and treating burn shock and promoting skin repair through a two-step procedure of covering and closing the wound. Currently, split-thickness/full-thickness skin autografts are the gold standard for permanent skin substitution. However, deep burns treated with split-thickness skin autografts may contract, leading to functional and appearance issues. Conversely, defects treated with full-thickness skin autografts often result in more satisfactory function and appearance. The development of tissue-engineered dermal templates has further expanded the scope of wound repair, providing scar reductive and regenerative properties that have extended their use to reconstructive surgical interventions. Although their interactions with the wound microenvironment are not fully understood, these templates have shown potential in local infection control. This narrative review discusses the current state of wound repair in burn injuries, focusing on the progress made from wound cover to wound closure and local infection control. Advancements in technology and therapies hold promise for improving the outcomes for burn injury patients. Understanding the underlying mechanisms of wound repair and tissue regeneration may provide new insights for developing more effective treatments in the future.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2025
Electronic address	https://doi.org/10.1016/j.jss.2023.12.043

Number of the records: 1