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Biodegradable covalently crosslinked poly[N-(2-hydroxypropyl) methacrylamide] nanogels: preparation and physicochemical properties
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SYSNO ASEP 0581942 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biodegradable covalently crosslinked poly[N-(2-hydroxypropyl) methacrylamide] nanogels: preparation and physicochemical properties Author(s) Kousalová, Jana (UMCH-V) RID, ORCID
Šálek, Petr (UMCH-V) RID, ORCID
Pavlova, Ewa (UMCH-V) RID
Konefal, Rafal (UMCH-V) RID, ORCID
Kobera, Libor (UMCH-V) RID, ORCID
Brus, Jiří (UMCH-V) RID, ORCID
Kočková, Olga (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDArticle number 263 Source Title Polymers. - : MDPI
Roč. 16, č. 2 (2024)Number of pages 17 s. Language eng - English Country CH - Switzerland Keywords biodegradable ; dispersion polymerization ; glutathione Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 001153027000001 EID SCOPUS 85183324052 DOI 10.3390/polym16020263 Annotation Recently, suitably sized polymer-based nanogels containing functional groups for the binding of biologically active substances and ultimately degradable to products that can be removed by glomerular filtration have become extensively studied systems in the field of drug delivery. Herein, we designed and tailored the synthesis of hydrophilic and biodegradable poly[N-(2-hydroxypropyl) methacrylamide-co-N,N′-bis(acryloyl) cystamine-co-6-methacrylamidohexanoyl hydrazine] (PHPMA-BAC-BMH) nanogels. The facile and versatile dispersion polymerization enabled the preparation of nanogels with a diameter below 50 nm, which is the key parameter for efficient and selective passive tumor targeting. The effects of the N,N′-bis(acryloyl) cystamine crosslinker, polymerization composition, and medium including H2O/MetCel and H2O/EtCel on the particle size, particle size distribution, morphology, and polymerization kinetics and copolymer composition were investigated in detail. We demonstrated the formation of a 38 nm colloidally stable PHPMA-BAC-BMH nanogel with a core–shell structure that can be rapidly degraded in the presence of 10 mM glutathione solution under physiologic conditions. The nanogels were stable in an aqueous solution modeling the bloodstream, thus, these nanogels have the potential to become highly important carriers in the drug delivery of various molecules. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2025 Electronic address https://www.mdpi.com/2073-4360/16/2/263
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