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Biodegradable covalently crosslinked poly[N-(2-hydroxypropyl) methacrylamide] nanogels: preparation and physicochemical properties

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    SYSNO ASEP0581942
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleBiodegradable covalently crosslinked poly[N-(2-hydroxypropyl) methacrylamide] nanogels: preparation and physicochemical properties
    Author(s) Kousalová, Jana (UMCH-V) RID, ORCID
    Šálek, Petr (UMCH-V) RID, ORCID
    Pavlova, Ewa (UMCH-V) RID
    Konefal, Rafal (UMCH-V) RID, ORCID
    Kobera, Libor (UMCH-V) RID, ORCID
    Brus, Jiří (UMCH-V) RID, ORCID
    Kočková, Olga (UMCH-V) RID, ORCID
    Etrych, Tomáš (UMCH-V) RID, ORCID
    Article number263
    Source TitlePolymers. - : MDPI
    Roč. 16, č. 2 (2024)
    Number of pages17 s.
    Languageeng - English
    CountryCH - Switzerland
    Keywordsbiodegradable ; dispersion polymerization ; glutathione
    Subject RIVCD - Macromolecular Chemistry
    OECD categoryPolymer science
    R&D ProjectsLX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Method of publishingOpen access
    Institutional supportUMCH-V - RVO:61389013
    UT WOS001153027000001
    EID SCOPUS85183324052
    DOI10.3390/polym16020263
    AnnotationRecently, suitably sized polymer-based nanogels containing functional groups for the binding of biologically active substances and ultimately degradable to products that can be removed by glomerular filtration have become extensively studied systems in the field of drug delivery. Herein, we designed and tailored the synthesis of hydrophilic and biodegradable poly[N-(2-hydroxypropyl) methacrylamide-co-N,N′-bis(acryloyl) cystamine-co-6-methacrylamidohexanoyl hydrazine] (PHPMA-BAC-BMH) nanogels. The facile and versatile dispersion polymerization enabled the preparation of nanogels with a diameter below 50 nm, which is the key parameter for efficient and selective passive tumor targeting. The effects of the N,N′-bis(acryloyl) cystamine crosslinker, polymerization composition, and medium including H2O/MetCel and H2O/EtCel on the particle size, particle size distribution, morphology, and polymerization kinetics and copolymer composition were investigated in detail. We demonstrated the formation of a 38 nm colloidally stable PHPMA-BAC-BMH nanogel with a core–shell structure that can be rapidly degraded in the presence of 10 mM glutathione solution under physiologic conditions. The nanogels were stable in an aqueous solution modeling the bloodstream, thus, these nanogels have the potential to become highly important carriers in the drug delivery of various molecules.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Year of Publishing2025
    Electronic addresshttps://www.mdpi.com/2073-4360/16/2/263
Number of the records: 1  

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