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Radium targets for cyclotron production of .sup.225./sup.Ac in view of targeted alpha therapy
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SYSNO ASEP 0579004 Document Type A - Abstract R&D Document Type O - Ostatní Title Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy Author(s) Kellerbauer, A. (DE)
Malmbeck, R. (DE)
Carrpico De Almeida, C. (DE)
Jajcisinova, E. (BE)
Eloirdi, R. (DE)
Lebeda, Ondřej (UJF-V) RID, ORCID, SAI
Morgenstern, A. (DE)Number of authors 7 Source Title European Journal of Nuclear Medicine and Molecular Imaging. - : Springer - ISSN 1619-7070
Roč. 50, Supplement 1 (2023), S11-S11Number of pages 1 s. Publication form Print - P Action Annual Congress of the European Association of Nuclear Medicine (ENAM'23) Event date 09.09.2023 - 13.09.2023 VEvent location Vienna Country AT - Austria Event type WRD Language eng - English Country US - United States Keywords Ac-225 production ; radiology imaging ; alpha therapy OECD category Radiology, nuclear medicine and medical imaging Institutional support UJF-V - RVO:61389005 UT WOS 001084059700010 DOI 10.1007/s00259-023-06333-x Annotation Targeted alpha therapy using the radionuclide Ac-225 has shown remarkable beneft in clinical trials to patients sufering from various cancer types. Currently most Ac-225 is produced from a few sources of Th-229 existing worldwide. However, the total amount available is only sufcient for a few thousand patient doses. Given a projected demand that is several orders of magnitude higher, alternative paths for the production of Ac-225 must be developed. We have been investigating the route
using the Ra-226(p,2n)Ac-225 reaction. It is particularly attractive due to its large cross-section near 17 MeV proton energy and because it can be readily employed at a large number of cyclotron facilities. The excitation function of this reaction has been previously measured by us for a few energies, but discrepancies with calculations remain. Hence, new irradiation experiments are required to improve the knowledge of the excitation function to support the industrial production of Ac-225 via this route.Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2024 Electronic address https://doi.org/10.1007/s00259-023-06333-x
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