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Delivery of Mycobacterium tuberculosis epitopes by Bordetella pertussis adenylate cyclase toxoid expands HLA-E-restricted cytotoxic CD8+ T cells
- 1.0578969 - MBÚ 2024 RIV CH eng J - Journal Article
Badami, G.D. - La Manna, M.P. - Di Carlo, P. - Staněk, Ondřej - Linhartová, Irena - Caccamo, N. - Šebo, Peter - Dieli, F.
Delivery of Mycobacterium tuberculosis epitopes by Bordetella pertussis adenylate cyclase toxoid expands HLA-E-restricted cytotoxic CD8+ T cells.
Frontiers in Immunology. Roč. 14, December 1 (2023), č. článku 1289212. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT(CZ) LM2023053
EU Projects: European Commission(XE) 643558 - EMI-TB
Institutional support: RVO:61388971
Keywords : Tuberculosis * Mycobacterium tuberculosis * Bacille Calmette Guerin * CD8+ T cells * HLA-E * CyaA
OECD category: Microbiology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289212/full
Introduction: Tuberculosis (TB) remains the first cause of death from infection caused by a bacterial pathogen. Chemotherapy does not eradicate Mycobacterium tuberculosis (Mtb) from human lungs, and the pathogen causes a latent tuberculosis infection that cannot be prevented by the currently available Bacille Calmette Guerin (BCG) vaccine, which is ineffective in the prevention of pulmonary TB in adults. HLA-E-restricted CD8+ T lymphocytes are essential players in protective immune responses against Mtb. Hence, expanding this population in vivo or ex vivo may be crucial for vaccination or immunotherapy against TB.
Permanent Link: https://hdl.handle.net/11104/0347862
File Download Size Commentary Version Access Delivery of Mycobacterium tuberculosis.pdf 1 902.7 KB Author´s preprint open-access
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