Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery

Novotná, K., Tenora, L., Prchalová, E., Paule, J., Alt, J., Veeravalli, V., Lam, J., Wu, Y., Šnajdr, I., Gori, S., Mettu, V. S., Tsukamoto, T., Majer, P., Slusher, B. S., Rais, R. Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery. Journal of Medicinal Chemistry. 2023, 66(22), 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804. Available: doi: 10.1021/acs.jmedchem.3c01681.