The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’\nexperience of association studies to understand the genetic architecture of\npancreatic cancer

0577153 - ÚEM 2024 RIV US eng J - Journal Article
Campa, D. - Gentiluomo, M. - Stein, A. - Aoki, M.N. - Oliverius, M. - Vodičková, Ludmila - Jamroziak, K. - Theodoropoulos, G. - Pasquali, C. - Greenhalf, W. - Arcidiacono, P.G. - Uzunoglu, F.G. - Pezzilli, R. - Luchini, C. - Puzzono, M. - Loos, M. - Giaccherini, M. - Katzke, V. - Mambrini, A. - Kiudeliene, E. - Federico, K.E. - Johansen, J. - Hussein, T. - Mohelníková-Duchoňová, B. - van Eijck, C.H.J. - Vodička, Pavel - Červená, Klára … Total 97 authors
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’
experience of association studies to understand the genetic architecture of
pancreatic cancer.
Critical Reviews in Oncology Hematology. Roč. 186, jun. (2023), č. článku 104020. ISSN 1040-8428. E-ISSN 1879-0461
R&D Projects: GA MZd(CZ) NU21-07-00247; GA MŠMT LX22NPO5102
Institutional support: RVO:68378041
Keywords : pancreatic cancer * pancreatic ductal adenocarcinoma * pancreatic neuroendocrine tumors * intraductal papillary mucinous neoplasms * chronic pancreatitis * genetic epidemiology * consortium
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.2, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S1040842823001087?via%3Dihub

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.
Permanent Link: https://hdl.handle.net/11104/0346381