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Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients
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SYSNO ASEP 0576728 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients Author(s) Kosztyu, P. (CZ)
Hill, M. (CZ)
Jemelková, J. (CZ)
Czerneková, L. (CZ)
Kafková, L.R. (CZ)
Hrubý, M. (CZ)
Matoušovic, K. (CZ)
Vondrák, K. (CZ)
Zadražil, J. (CZ)
Šterzl, I. (CZ)
Městecký, Jiří (MBU-M) ORCID
Raška, M. (CZ)Source Title Kidney & Blood Pressure Research. - : Karger - ISSN 1420-4096
Roč. 43, č. 2 (2018), s. 350-359Number of pages 10 s. Language eng - English Country CH - Switzerland Keywords Iga nephropathy ; O-glycosylation ; IgA1 hinge region ; Circulating immune complexes ; Galactose deficiency ; Glycan-specific antibodies Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects NV15-33686A GA MZd - Ministry of Health (MZ) Method of publishing Open access UT WOS 000434716500005 EID SCOPUS 85054692240 DOI https://doi.org/10.1159/000487903 Annotation Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonresponding to angiotensin-converting enzyme inhibitors or angiotensin II blockers, corticosteroids are recommended. Methods: The relationship between the corticosteroid therapy and serum levels of IgA, aberrantly O-glycosylated IgA1, IgA-containing immune complexes and their mesangioproliferative activity was analyzed in IgA nephropathy patients and disease and healthy controls. Results: Prednisone therapy significantly reduced proteinuria and levels of serum IgA, galactose-deficient IgA1, and IgA-IgG immune complexes in IgA nephropathy patients and thus reduced differences in all of the above parameters between IgAN patients and control groups. A moderate but not significant reduction of mesangioproliferative potential of IgA-IgG immune complexes and IgA sialylation was detected. Conclusion: The prednisone therapy reduces overall aberrancy in IgA1 O-glycosylation in IgA nephropathy patients, but the measurement of IgA1 parameters does not allow us to predict the prednisone therapy outcome in individual patients. (C) 2018 The Author(s) Published by S. Karger AG, Basel. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2024 Electronic address https://karger.com/kbr/article/43/2/350/187867/Glucocorticoids-Reduce-Aberrant-O-Glycosylation-of
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