Number of the records: 1
Galectin-targeting glycocalix[4]arenes can enter the cells
- 1.0575861 - MBÚ 2024 RIV GB eng J - Journal Article
Vlachová, Miluše - Tran, V. N. - Červený, Jakub - Dolníček, F. - Petrásková, Lucie - Pelantová, Helena - Kundrát, O. - Cvačka, Josef - Bosáková, Z. - Křen, Vladimír - Lhoták, P. - Viktorová, J. - Bojarová, Pavla
Galectin-targeting glycocalix[4]arenes can enter the cells.
Chemical Communications. Roč. 59, č. 69 (2023), s. 10404-10407. ISSN 1359-7345. E-ISSN 1364-548X
R&D Projects: GA ČR(CZ) GA22-00317S
Institutional support: RVO:61388971 ; RVO:61388963
Keywords : galectin * calixarene * oligosaccharide * glycomimetic * epithel
OECD category: Biochemistry and molecular biology; Analytical chemistry (UOCHB-X)
Impact factor: 4.9, year: 2022
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC02905K
Elevated levels of galectin-3 are associated with tumorigenesis. Its inhibition with high-affinity carbohydrate ligands opens new therapeutic routes. Targeting of intracellular galectin-3 is challenging for polar inhibitors like carbohydrates. We demonstrate the potential of novel biomedical research tools, glycocalix[4]arenes, to enter epithelial cells, which may allow their interaction with galectin-3.
Permanent Link: https://hdl.handle.net/11104/0345563
Number of the records: 1