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Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice
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SYSNO ASEP 0573086 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice Author(s) Schwarzer, Martin (MBU-M) ORCID, RID
Gautam, Umesh Kumar (MBU-M)
Makki, K. (FR)
Lambert, A. (FR)
Brabec, Tomáš (UMG-J)
Joly, A. (FR)
Šrůtková, Dagmar (MBU-M) ORCID, RID
Poinsot, P. (FR)
Novotná, Tereza (MBU-M)
Geoffroy, S. (FR)
Courtin, P. (FR)
Hermanová, Petra (MBU-M) ORCID
Matos, R. C. (FR)
Landry, J. J. M. (DE)
Gérard, C. (FR)
Bulteau, A. (FR)
Hudcovic, Tomáš (MBU-M) RID, ORCID
Kozáková, Hana (MBU-M) RID, ORCID
Filipp, Dominik (UMG-J) RID
Chapot-Chartier, M. (FR)
Šinkora, Marek (MBU-M) RID, ORCID
Peretti, N. (FR)
Boneca, I. G. (FR)
Chamaillard, M. (FR)
Vidal, H. (FR)
De Vadder, F. (FR)
Leulier, F. (FR)Number of authors 27 Source Title Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 379, č. 6634 SI (2023), s. 826-833Number of pages 8 s. Language eng - English Country US - United States Keywords intestinal microbiota ; LpWJLsustains ; NOD2 ; IGF-1 OECD category Microbiology Subject RIV - cooperation Institute of Molecular Genetics - Immunology R&D Projects GM21-19640M GA ČR - Czech Science Foundation (CSF) GJ18-07015Y GA ČR - Czech Science Foundation (CSF) GA20-30350S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support MBU-M - RVO:61388971 ; UMG-J - RVO:68378050 UT WOS 000981616600014 EID SCOPUS 85148680225 DOI 10.1126/science.ade9767 Annotation The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJLsustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2024 Electronic address https://www.science.org/doi/10.1126/science.ade9767
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