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Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling
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SYSNO ASEP 0572441 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling Author(s) Qiu, T. (GB)
Hutečková, Barbora (UZFG-Y)
Seppala, M. (GB)
Cobourne, M. (GB)
Chen, Z. (CN)
Hovořáková, M. (CZ)
Buchtová, Marcela (UZFG-Y) RID, ORCID
Tucker, A. S. (GB)Number of authors 8 Article number dev201464 Source Title Development. - : Company of Biologists - ISSN 0950-1991
Roč. 150, č. 7 (2023)Number of pages 13 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords Vestibular lamina ; Oral cavity ; Sonic hedgehog ; Gas1 ; Dental lamina ; Ciliopathies ; Mouse Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology R&D Projects GA21-04178S GA ČR - Czech Science Foundation (CSF) GA18-04859S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UZFG-Y - RVO:67985904 UT WOS 000982526000007 EID SCOPUS 85152165771 DOI 10.1242/dev.201464 Annotation The vestibular lamina (VL) forms the oral vestibule, creating a gap between the teeth, lips and cheeks. In a number of ciliopathies, formation of the vestibule is defective, leading to the creation of multiple frenula. In contrast to the neighbouring dental lamina, which forms the teeth, little is known about the genes that pattern the VL. Here, we establish a molecular signature for the usually non-odontogenic VL in mice and highlight several genes and signalling pathways that may play a role in its development. For one of these, the Sonic hedgehog (Shh) pathway, we show that co-receptors Gas1, Cdon and Boc are highly expressed in the VL and act to enhance the Shh signal from the forming incisor region. In Gas1 mutant mice, expression of Gli1 was disrupted and the VL epithelium failed to extend due to a loss of proliferation. This defect was exacerbated in Boc/Gas1 double mutants and could be phenocopied using cyclopamine in culture. Signals from the forming teeth, therefore, control development of the VL, coordinating the development of the dentition and the oral cavity. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2024 Electronic address https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=45564202388
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