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Identification of GC-rich LAT genes in birds
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SYSNO ASEP 0572429 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Identification of GC-rich LAT genes in birds Author(s) Janušová, Šárka (UMG-J) ORCID
Krchlíková, Veronika (UMG-J)
Hron, Tomáš (UMG-J)
Elleder, Daniel (UMG-J) RID
Štěpánek, Ondřej (UMG-J) RID, ORCIDNumber of authors 5 Article number e0283431 Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 18, č. 4 (2023)Number of pages 8 s. Language eng - English Country US - United States Keywords T-CELL-RECEPTOR ; ACTIVATION ; LINKER ; PHOSPHORYLATION ; MUTATION ; PROTEINS OECD category Biochemistry and molecular biology R&D Projects LX22NPO5103 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000969434300008 EID SCOPUS 85151803411 DOI 10.1371/journal.pone.0283431 Annotation Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling in mammals. Accordingly, LAT orthologues were identified in the majority of vertebrates. However, LAT orthologues were not identified in most birds. In this study, we show that LAT gene is present in genomes of multiple extant birds. It was not properly assembled previously because of its GC-rich content. LAT expression is enriched in lymphoid organs in chicken. The analysis of the coding sequences revealed a strong conservation of key signaling motifs in LAT between chicken and human. Overall, our data indicate that mammalian and avian LAT genes are functional homologues with a common role in T-cell signaling. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2024 Electronic address https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283431
Number of the records: 1