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4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats
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SYSNO ASEP 0572030 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title 4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats Author(s) Štěpánková, Kateřina (UEM-P) ORCID
Mareková, Dana (UEM-P)
Kubášová, K. (CZ)
Sedláček, R. (CZ)
Turnovcová, Karolína (UEM-P) ORCID
Vacková, Irena (UEM-P)
Kubinová, Šárka (UEM-P) RID, ORCID
Makovický, P. (SK)
Petrovičová, M. (CZ)
Kwok, Jessica (UEM-P) ORCID, RID
Jendelová, Pavla (UEM-P) RID, ORCID
Machová-Urdzíková, Lucia (UEM-P) ORCIDArticle number 3799 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 24, č. 4 (2023)Number of pages 23 s. Language eng - English Country CH - Switzerland Keywords hyaluronan ; 4-methylumbelliferone ; chondroitin sulphates ; neuroplasticity OECD category Toxicology R&D Projects EF15_003/0000419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-10365S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000945189900001 EID SCOPUS 85149002553 DOI 10.3390/ijms24043799 Annotation 4-methylumbelliferone (4MU) has been suggested as a potential therapeutic agent for a wide range of neurological diseases. The current study aimed to evaluate the physiological changes and potential side effects after 10 weeks of 4MU treatment at a dose of 1.2 g/kg/day in healthy rats, and after 2 months of a wash-out period. Our findings revealed downregulation of hyaluronan (HA) and chondroitin sulphate proteoglycans throughout the body, significantly increased bile acids in blood samples in weeks 4 and 7 of the 4MU treatment, as well as increased blood sugars and proteins a few weeks after 4MU administration, and significantly increased interleukins IL10, IL12p70 and IFN gamma after 10 weeks of 4MU treatment. These effects, however, were reversed and no significant difference was observed between control treated and 4MU-treated animals after a 9-week wash-out period. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://www.mdpi.com/1422-0067/24/4/3799
Number of the records: 1