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Interaction between nanomaterials and the innate immune system across evolution
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SYSNO ASEP 0571675 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Interaction between nanomaterials and the innate immune system across evolution Author(s) Boraschi, D. (IT)
Canesi, L. (IT)
Drobne, D. (SI)
Kemmerling, B. (DE)
Pinsino, A. (IT)
Procházková, Petra (MBU-M) RID, ORCIDSource Title Biological Reviews. - : Wiley - ISSN 1464-7931
Roč. 98, č. 3 (2023), s. 747-774Number of pages 28 s. Language eng - English Country US - United States Keywords innate immunity ; Toll-like receptors ; phagocytes ; plants ; invertebrates ; human ; in vivo ; in vitro OECD category Immunology R&D Projects LO1509 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000913971400001 EID SCOPUS 85146339127 DOI 10.1111/brv.12928 Annotation Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno-nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity is the first line of immune reactivity towards exogenous agents and is highly conserved throughout evolution, this review focuses on the major effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll-like receptors (TLRs), for assessing the modes of successful versus pathological interaction between ENMs and host defences. By comparing the phagocyte- and TLR-dependent responses to ENMs in plants, molluscs, annelids, crustaceans, echinoderms and mammals, we aim to highlight common recognition and elimination mechanisms and the general sufficiency of innate immunity for maintaining tissue integrity and homeostasis. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2024 Electronic address https://onlinelibrary.wiley.com/doi/10.1111/brv.12928
Number of the records: 1