Self-activated antibacterial MOF-based coating on medically relevant polypropylene

0570888 - ÚMCH 2024 RIV NL eng J - Journal Article
Skvortsova, A. - Kociánová, A. - Guselnikova, O. - Elashnikov, R. - Burtsev, V. - Rimpelová, S. - Svobodova Pavlickova, V. - Fitl, P. - Lukešová, Miroslava - Kolská, Z. - Švorčík, V. - Lyutakov, O.
Self-activated antibacterial MOF-based coating on medically relevant polypropylene.
Applied Surface Science. Roč. 623, 30 June (2023), č. článku 157048. ISSN 0169-4332. E-ISSN 1873-5584
Institutional support: RVO:61389013
Keywords : polypropylene * surface antimicrobial protection * metal–organic frameworks
OECD category: Polymer science
Impact factor: 6.7, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0169433223007250?via%3Dihub

Modern medicine is virtually unimaginable without using various auxiliary materials and devices such as catheters or implants. In this context, there is a potential risk of bacterial colonization and biofilm formation on the surface of these devices, which can lead to serious infections and endanger the health of patients. To prevent bacterial colonization, the preparation and utilization of an intelligent self-activating antibacterial coating on the surface of medically-relevant polypropylene (PP) are proposed in this work. The 3D periodic metal–organic framework structure (copper-1,3,5-benzenetricarboxylate, further referred as CuBTC) was covalently immobilized on the surface of the PP film. The immobilized CuBTC layer can effectively release NO• radicals from its endogenous donor – S-Nitrosoglutathion (GSNO). Local NO• generation ensures the surface antifouling properties and efficiently inhibits the bacterial adhesion to PP. Unlike materials requiring an external stimulus to activate their antibacterial properties, the proposed coating responds to increasing concentration of GSNO in body fluids (increasing of GSNO concentration is commonly associated with bacterial infection and inflammatory response). So that, the proposed coating can be efficiently self-activated on the right place and at the right time. Considering the application area of medical PP, we also estimated the stability of CuBTC antimicrobial response.
Permanent Link: https://hdl.handle.net/11104/0342223