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Milling of pharmaceutical powder carrier excipients: Application of central composite design
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SYSNO ASEP 0565992 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Milling of pharmaceutical powder carrier excipients: Application of central composite design Author(s) Marushka, J. (CZ)
Brokešová, J. (CZ)
Ugo Ogadah, Ch. (CZ)
Kazemi, A. (CZ)
Duintjer Tebbens, Jurjen (UIVT-O) RID, SAI, ORCID
Šklubalová, Z. (CZ)Number of authors 6 Article number 103881 Source Title Advanced Powder Technology. - : Elsevier - ISSN 0921-8831
Roč. 33, č. 12 (2022)Number of pages 9 s. Publication form Online - E Language eng - English Country NL - Netherlands Keywords Excipient ; Milling ; Quality by design ; Particle size OECD category Pharmacology and pharmacy Method of publishing Limited access Institutional support UIVT-O - RVO:67985807 UT WOS 000892295100007 EID SCOPUS 85142135929 DOI 10.1016/j.apt.2022.103881 Annotation Pharmaceutical powder carriers are often used to prevent agglomeration of a micronized drug in the co-milling process. Twenty-four pharmaceutical excipients were subjected to preliminary mild milling conditions in this work. Ten of them showed acceptable milling properties with alginic acid, calcium alginate, microcrystalline cellulose (Avicel® 200), carrageenan, and hypromellose having the best particle size reduction without any aggregation while maintaining a narrow span. For the latter five substances, circumscribed central composite design (CCD) evaluating the effect of the factors milling speed and timeon the responses (particle size, particle size distribution) for three milling ball sizes was used to establish optimal milling conditions. For all ten possible factor combinations and each ball size, a quadratic response surface model was used to predict the response variable. For three substances out of five, the best results were achieved using 5-mm balls. Thermal characteristics showed the good stability of excipients under optimized milling conditions. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2023 Electronic address https://dx.doi.org/10.1016/j.apt.2022.103881
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