Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges

0556676 - FGÚ 2023 RIV US eng J - Journal Article
Ehrlich, H. - Luczak, M. - Ziganshin, R. - Mikšík, Ivan - Wysokowski, M. - Simon, P. - Baranowska-Bosiacka, I. - Kupnicka, P. - Ereskovsky, A. - Galli, R. - Dyshlovoy, S. - Fischer, J. - Tabachnick, K. R. - Petrenko, I. - Jesionowski, T. - Lubkowska, A. - Figlerowicz, M. - Ivanenko, V. N. - Summers, A. P.
Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges.
Advanced Science. Roč. 9, č. 11 (2022), č. článku 2105059. E-ISSN 2198-3844
R&D Projects: GA ČR(CZ) GA20-03899S
Institutional support: RVO:67985823
Keywords : actin * biological materials * biomineralization * biosilica * sponges
OECD category: Analytical chemistry
Impact factor: 15.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/advs.202105059

Actin is a fundamental member of an ancient superfamily of structural intracellular proteins and plays a crucial role in cytoskeleton dynamics, ciliogenesis, phagocytosis, and force generation in both prokaryotes and eukaryotes. It is shown that actin has another function in metazoans: patterning biosilica deposition, a role that has spanned over 500 million years. Species of glass sponges (Hexactinellida) and demosponges (Demospongiae), representatives of the first metazoans, with a broad diversity of skeletal structures with hierarchical architecture unchanged since the late Precambrian, are studied. By etching their skeletons, organic templates dominated by individual F-actin filaments, including branched fibers and the longest, thickest actin fiber bundles ever reported, are isolated. It is proposed that these actin-rich filaments are not the primary site of biosilicification, but this highly sophisticated and multi-scale form of biomineralization in metazoans is ptterned.
Permanent Link: http://hdl.handle.net/11104/0330793