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Role of membrane proteins in bacterial resistance to antimicrobial peptides
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SYSNO ASEP 0556539 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Role of membrane proteins in bacterial resistance to antimicrobial peptides Author(s) Vimberg, Vladimír (MBU-M) ORCID
Buriánková, Karolína (MBU-M) RID
Mazumdar, Aninda (MBU-M)
Branny, Pavel (MBU-M) RID, ORCID
Novotná, Gabriela (MBU-M)Source Title Medicinal Research Reviews. - : Wiley - ISSN 0198-6325
Roč. 42, č. 3 (2022), s. 1023-1036Number of pages 14 s. Language eng - English Country US - United States Keywords staphylococcus-aureus ; in-vitro ; teicoplanin resistance ; telavancin activity ; confers resistance ; vancomycin ; oritavancin ; dalbavancin ; vrasr ; tcaa ; antimicrobial peptides ; gram-positive bacteria ; lipoglycopeptide antibiotics ; membrane proteins ; resistance Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LTAUSA18112 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-03269S GA ČR - Czech Science Foundation (CSF) NV15-28807A GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support MBU-M - RVO:61388971 UT WOS 000720267700001 EID SCOPUS 85119292891 DOI 10.1002/med.21869 Annotation Several natural antimicrobial peptides (AMPs), including the novel semisynthetic lipoglycopeptide antibiotics telavancin, dalbavancin, and oritavancin, have been approved for clinical use to address the growing problem of multiple antibiotic-resistant Gram-positive bacterial infections. Nevertheless, the efficacy of these antibiotics has already been compromised. The SARS-CoV-2 pandemic led to the increased clinical use of all antibiotics, further promoting the development of bacterial resistance. Therefore, it is critical to gain a deeper understanding of the role of resistance mechanisms to minimize the consequential risks of long-term antibiotic use and misuse. Here, we summarize for the first time the current knowledge of resistance mechanisms that have been shown to cause resistance to clinically used AMPs, with particular focus on membrane proteins that have been reported to interfere with the activity of AMPs by affecting the binding of AMPs to bacteria. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2023 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/med.21869
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