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Effects of high magnetic fields on the diffusion of biologically active molecules
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SYSNO ASEP 0556091 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of high magnetic fields on the diffusion of biologically active molecules Author(s) Zablotskii, Vitalii (FZU-D) ORCID
Polyakova, Tetyana (FZU-D) ORCID
Dejneka, Alexandr (FZU-D) RID, ORCIDNumber of authors 3 Article number 81 Source Title Cells. - : MDPI - ISSN 2073-4409
Roč. 11, č. 1 (2022)Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords magnetic field ; molecular diffusion ; drug diffusion ; hemoglobin ; red blood cells Subject RIV BO - Biophysics OECD category Particles and field physics R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000741737300001 EID SCOPUS 85122298234 DOI https://doi.org/10.3390/cells11010081 Annotation The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2023 Electronic address http://hdl.handle.net/11104/0330472
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