Number of the records: 1
Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides
- 1.
SYSNO ASEP 0555337 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides Author(s) Jernfors, T. (FI)
Danforth, J. (CA)
Kesaniemi, J. (FI)
Lavrinienko, A. (FI)
Tukalenko, E. (FI)
Fajkus, Jiří (BFU-R) RID, ORCID
Dvořáčková, M. (CZ)
Mappes, T. (FI)
Watts, P. (FI)Number of authors 9 Source Title Ecology and Evolution. - : Wiley - ISSN 2045-7758
Roč. 11, č. 13 (2021), s. 8754-8767Number of pages 14 s. Publication form Print - P Language eng - English Country US - United States Keywords chernobyl exclusion zone ; dna-damage response ; ionizing-radiation ; repetitive dna ; nuclear-organization ; 50 generations OECD category Ecology Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000653643300001 EID SCOPUS 85106333786 DOI 10.1002/ece3.7684 Annotation Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from external stressors. We quantified copy number of the 18S rDNA and a pericentromeric satellite DNA (Msat-160) in bank voles (Myodes glareolus) inhabiting the Chernobyl Exclusion Zone (CEZ), an area that is contaminated by radionuclides and where organisms are exposed to elevated levels of ionizing radiation. We found a significant increase in 18S rDNA and Msat-160 content in the genomes of bank voles from contaminated locations within the CEZ compared with animals from uncontaminated locations. Moreover, 18S rDNA and Msat-160 copy number were positively correlated in the genomes of bank voles from uncontaminated, but not in the genomes of animals inhabiting contaminated, areas. These results show the capacity for local-scale geographic variation in genome architecture and are consistent with the genomic safeguard hypothesis. Disruption of cellular processes related to genomic stability appears to be a hallmark effect in bank voles inhabiting areas contaminated by radionuclides. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2022 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/ece3.7684
Number of the records: 1