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Modular Synthesis of Dendritic Amphiphiles.
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SYSNO ASEP 0553686 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Modular Synthesis of Dendritic Amphiphiles. Author(s) Edr, Antonín (UCHP-M) ORCID, RID, SAI
Kalasová, J. (CZ)
Malý, J. (CZ)
Strašák, Tomáš (UCHP-M) RID, ORCID, SAISource Title Czech Chemial Society Symposium Series, Vol 19, No 1. - Praha : Česká společnost chemická, 2021 / Řápková R. ; Fusek M. ; Drašar P. - ISSN 2336-7202
S. 12-13Number of pages 2 s. Publication form Online - E Action Interdisciplinary Meeting of Young Biologists, Biochemists and Chemists /20./ on-line meeting Event date 17.05.2021 - 20.05.2021 Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords modular synthesis ; dendritic amphiphiles ; dendrons Subject RIV CC - Organic Chemistry OECD category Organic chemistry Institutional support UCHP-M - RVO:67985858 Annotation Among nanovesicle drug delivery systems, liposomes are the oldest and most widely used
vehicles. To overcome some of their drawbacks, analogical supramolecular systems based on
different building blocks were developed in two recent decades. Next to polymersomes or
exosomes, an attention is turned to so-called dendrimersomes.3,4 Dendrimersomes are
nanovesicles most usually self-assembled from so-called Janus dendrimers. These dendrimers
consist of two different dendrons, where one bears lipophilic groups on its periphery and one
bears polar groups. Following dendrimersomes design, this project aims on preparation of
similar nanovesicles from amphiphilic molecules with one dendritic positively charged part and
one part formed by linear lipophilic alkyl chains as in the case of building blocks of liposomes. In the aqueous solution, these amphiphiles should be able to self-assemble into supramolecular objects. These supramolecular objects could then serve as nanovehicles for variety of drugs or nucleic acids with therapeutic effects. The project is specially focused on delivery of siRNA (short interfering RNA).Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2022
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